The Masterclass by IFCN presentations were created in response to a call from IFCN members societies for more high quality, complimentary, online educational content. The series will provide a new presentation every month from top clinical neurophysiologists around the world, and each will include time for discussion with the lecturer following the presentation.
Providing the best in contemporary clinical neurophysiology education delivered in the most optimal format is the primary educational goal of the IFCN. As such, Masterclass by IFCN will be available complimentary to all registrants.
The Masterclass by IFCN presentation:
"Diagnostic Significance of Sleep, EEG and Silent Seizures in Preclinical and Early Alzheimer’s Disease"
will take place on Saturday, April 23, 2022 at 9:00 am EDT (3:00 pm CET).
Professor Madeleine Grigg-Damberger will present Diagnostic Significance of Sleep, EEG and Silent Seizures in Preclinical and Early Alzheimer’s Disease
Clinical neurophysiologists need to understand the complex bidirectional relationships between sleep and the later development of dementia. Insufficient sleep contributes to amyloid beta and tau brain burden in preclinical and early Alzheimer’s disease (AD). Impaired phase coupling between sleep spindles, hippocampal ripples and slow oscillations in NREM sleep is associated with tau deposition in the hippocampus and impaired memory consolidation in cognitively normal older adults. Elevated orexin, sleep apnea, nocturnal hypoxia and excitotoxicity further increase AD risk. Silent seizures in early AD often go unrecognized without sleep EEG. Sleep a potentially modifiable risk factor for AD.