Begrunnelse:
Forekomst av oxytocinstimulering er høy, flere studier finner også utstrakt feilbruk av medikamentet. Tidlig oxytocinstimulering sammenlignet med avventende fører til kortere fødsel, men ikke til endring i andre utfall. Derimot kan oxytocinstimulering medføre for tette rier (hyperstimulering), og det er vist en mulig sammenheng mellom oxytocinstimuering og operative forløsninger og økt risiko for lavere Apgar-score og flere innleggelser på nyfødtavdeling.
Referanser:
- The Labor Progression Study: The use of oxytocin augmentation during labor following Zhang's guideline and the WHO partograph in a cluster randomized trial Dalbye et al
Acta Obstet Gynecol Scand. 2019 Sep;98(9):1187-1194. doi: 10.1111/aogs.13629. Epub 2019 Jun 14. - Effects of oxytocin-induced uterine hyperstimulation during labor on fetal oxygen status and fetal heart rate patterns. Simpson & James Am J Obstet Gynecol. 2008 Jul;199(1):34.e1-5. doi: 10.1016/j.ajog.2007.12.015. Epub 2008 Mar 14.
- Outcome in obstetric care related to oxytocin use. Oscarsson et al A population‐based study. Acta Obstet Gynecol Scand. 2006;85(9):1094‐1098.
- Oxytocin and dystocia as risk factors for adverse birth outcomes: a cohort of low‐risk nulliparous women. Bernitz et al. Midwifery. 2014;30(3):364‐370.
- De-medicalization of birth by reducing the use of oxytocin for augmentation among firsttime mothers - a prospective intervention study Gaudernack et al 2018 BMC Pregnancy Childbirth. 2018 Mar 27;18(1):76. doi: 10.1186/s12884-018 1706-4.
- Discontinuing Oxytocin Infusion in the Active Phase of Labor: A Systematic Review and Metaanalysis. Saccone et al Obstet Gynecol. 2017 Nov;130(5):1090-1096. doi: 10.1097/AOG.0000000000002325.
- High-dose versus low-dose of oxytocin for labour augmentation: a randomised controlled trial. Selin et al Women Birth.Aug;32(4):356-363. doi: 10.1016/j.wombi.2018.09.002. Epub 2018 Oct 16.
- Early versus delayed oxytocin augmentation in nulliparous women with prolonged labour--a randomised controlled trial. Dencker et al BJOG. 2009 Mar;116(4):530-6. doi: 10.1111/j.1471-0528.2008.01962.x.